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Frequently Asked Questions

Frequently asked questions about Alflorex and IBS. Find your answer.

About Alflorex for IBS

What is Alflorex for IBS?

Alflorex para Irritable Colon is a medical device containing the unique strain 35624 of Bifidobacterium longum, which has clinically shown its effectiveness against all symptoms of the irritable bowel. Each capsule of Alflorex contains one billion bacteria (1x109).

Alflorex has been jointly researched and developed by scientists, clinicians and gastroenterologists from Alimentary Health Ltd. and University College Cork in Ireland, one of the world"s leading institutions in probiotic research.

What is strain 35624?

35624 is the name of the trademark registered by Alimentary Health for the probiotic strain Bifidobacterium longum 35624. A strain that has been shown to be effective in treating symptoms associated with Irritable Bowel Syndrome (IBS).

Not all strains of the same family have the same effects on the body, nor are they all beneficial. The 35624 strain has more than 20 years of scientific research, more than 75 publications, a significant history of consumption for more than 15 years and is the No. 1 of the most recommended probiotics by gastroenterologists in the US.

Is the live strain of Alflorex of Irritable Colon of natural origin?

Yes. Alflorex for IBS contains strain 35624 of Bifidobacterium longum, a living bacterial strain found naturally in the human gut. It belongs to the Bifidobacterium family of bacteria, which mothers transmit to their babies at birth.

To ensure that this natural strain reaches the gut alive and addresses symptoms of the irritable colon, a stable and easy-to-take formulation has been developed. This stable formulation also ensures that Alflorex para Colon Irritable does not need refrigeration.

Why is Alflorex different?

Alflorex is the only product in Europe that contains the unique 35624 live bacterial culture, for the specific treatment of symptoms of the irritable bowel.

This culture has been clinically tested by leading scientists and gastroenterologists. The results of these trials have been published in a wide range of respected scientific journals.

The live 35624 culture in Alflorex is a type of bacteria that occurs naturally in the human gut. It"s part of the Bifidobacterium group, one of the first kinds of bacteria passed by mothers to their babies at birth.

How many bacteria does each capsule of Alflorex contain?

A single Alflorex capsule contains around 1 billion live bacteria, or 1x109 colony forming units (CFUs), at the time of manufacture. 

The quantity of bacteria provided in each capsule has been chosen for optimal balance in the gut. The dose in the capsule remains effective throughout its shelf life.

Will Alflorex reach my bowel in peak condition?

Yes. The 35624 culture in Alflorex for IBS has been shown in 4 clinical trials, reported in respected scientific publications, to remain active right through the digestive system and to reach the bowel with its properties intact.

Who is Alflorex for Irritable Colon for?

Alflorex for IBS is especially indicated in the treatment of typical symptoms of the Irritable Bowel: bloating, flatulence, abdominal pain, constipation and/or diarrhea.

Taking Alflorex for IBS

How quickly does Alflorex work?

Alflorex for IBS acts immediately and begins to prime your gut when it is needed. This activity takes approximately 4 weeks*. It is important to take Alflorex every day.

Some people may experience mild and temporary changes in their gut during this first 4 weeks as Alflorex begins to gently prime the gut. If you have any questions at all about how Alflorex is working for you, please contact us.

*In rare cases it may take Alflorex longer than 4 weeks to prime the gut, possibly up to 8 weeks. If you"d like to talk about this and taking Alflorex, please contact us.

What should I expect when taking Alflorex for IBS?

The 35624 live culture is part the Bifidobacterium family, one of the first kinds of bacteria passed by mothers to their babies at birth. Hence it is at home in the human gut.

Initial symptoms relief is observed approximately after 1-2 weeks of taking Alflorex for IBS on a regular basis. Rarely, Alflorex may require more than 1 month to readjust the intestine, even up to 2-3 months.

Some people may experience mild and temporary changes in their gut during the first 4 weeks as Alflorex begins to gently prime the gut. It is recommended not to stop taking it. 

If you have any questions at all about how Alflorex is working for you, please contact us.

What is the best time of the day to take Alflorex?

Whenever you like. It is not important the time of the day when you take Alflorex. The most important thing is to take it daily. It is recommended to take Alflorex as a lifestyle routine, when it is easier to remember your take. It can be taken with or without food.

How small is an Alflorex for IBS capsule?

An Alflorex capsule is a size 3 capsule, one of the smallest sizes available.

How should I take Alflorex for IBS?

Take 1 capsule a day, with or without food, at any time of the day.

Alflorex for IBS capsules have been formulated to be swallowed whole, with water, milk or non-acid juices. If there is difficulty swallowing, the capsules can be opened and mixed with the cold or temperate food or drink to be consumed immediately. Emptying the contents in a hot food or drink is not recommended.

If I forget to take Alflorex for Irritable Colon, what should I do?

If you miss a day taking your dose, you do not need to double it the next day. Continue with the indicated 1 capsule per day.

How long should I take Alflorex for IBS for and what happens if I stop?

Alflorex IBS should be taken daily. The 35624 live bacterial culture in Alflorex stays in your gut for as long as you continue to take the product. It performs its action in the gut and then will naturally be swept out by regular bowel movements.

The recommendation is to take Alflorex for 4 weeks to prepare the intestine and then continue taking it daily to maintain its effect. Very rarely has the strain 35624 needed more than 4 weeks to prepare the gut, but it can reach up to 8-12 weeks.

By taking a single capsule of Alflorex every day you can ensure your gut remains primed.

Why should I avoid taking Alflorex for IBS with fruit juices?

Fruit juices are generally acidic, and acid can damage the 35624 culture, making it less effective. So, we recommend taking Alflorex for IBS with water or milk or less acidic drinks like soya, almond or rice milks.

However, Alflorex for IBS can be taken as part of a meal that has fruit juice, as the food will help protect the Alflorex culture.

Can you take Alflorex for IBS with alcohol?

Like any living microorganism, the active strain of Alflorex for IBS, Bifidobacterium longum 35624, can be inactivated by alcohol. 

We recommend not drinking alcohol at the same time or for a few hours after taking Alflorex for IBS.

Does Alflorex for IBS contain any dye?

Alflorex for IBS does not carry titanium dioxide or any other dye.

Is Alflorex allergy free? Gluten free? Dairy free? Lactose free? Soya free?

Yes. There are no known allergens in Alflorex for IBS. 

Alflorex for IBS DOES NOT CONTAIN gluten, milk or dairy derivatives, soy, sugar, sweeteners, preservatives or dyes. It is indicated for patients with lactose intolerance, dairy derivatives or soya allergies.

All raw materials used for Alflorex for IBS do not contain any allergen listed in the Directive 2007/68/EC and its amendments. The facilities we use to manufacture also ensure that during the production process, raw materials are not exposed to allergens cross contamination.

Is Alflorex for Irritable Colon suitable for diabetics?

Yes. Each capsule contains only a residual amount of sugar and does not affect blood glucose levels.

Is Alflorex for IBS is suitable for people who follow vegetarian, vegan, halal or kosher diets?


Is Aflorex for IBS suitable for those on a low FODMAP diet?


Does Alflorex for IBS need to be refrigerated?

No. It just needs to be stored at under 25oC and in a dry environment.

Alflorex for IBS has been carefully formulated to be stable at room temperature and does not need to be refrigerated.

The special packaging for Alflorex for IBS capsules means that they can travel with you and keep their qualities.

How much does Alflorex for IBS cost?

Alflorex for IBS costs less than €1 per day and enables you to regain control of your gut health.

Where can I buy Alflorex for IBS?

In Spain, Alflorex for IBS is available in pharmacies. You can purchase it without a prescription.

If Alflorex is not available on the shelf, the pharmacist can order it immediately and receive it in a few hours.

You can also order it through online pharmacies.

Alflorex for IBS safety

Is Alflorex for Irritable Colon well tolerated?

The 35624 strain of Bifidobacterium longum is well tolerated. 

Alflorex for IBS has been used for more than 15 years by tens of thousands of consumers in the United States, Canada and Europe. Because of its presence on the QPS (Qualified Safety Presumption) list, the bacterial strain of Alflorex for IBS is recognized as safe by the European Agency EFSA (European Food Safety Authority).

Are there side effects with Alflorex for IBS?

The 35624 culture in Alflorex has been studied by doctors and scientists in well run clinical trials. No safety concerns were identified. The safety of the product has also been confirmed in scientific reviews.

The 35624 bacteria are part of the Bifidobacterium family of bacteria, one of the first types of bacteria from mothers to their babies at birth.

There are no known side effects with Alflorex.

Some people may experience mild and temporary changes in their gut during the first 4 weeks as Alflorex for IBS begins to gently prime the gut.

Is Alflorex safe to take with medicine?

No side effects in conjunction with the use of Alflorex for IBS have been observed to date.

There are no known interactions with any medications. However, Alflorex for IBS is composed of bacteria that, like any probiotic, can be destroyed by simultaneous intake with antibiotics, so it is advisable to separate the time of day to take one and the other product.

On the other hand, if you have a serious or chronic illness, if you are wondering if Alflorex for Irritable Colon is right for you, or if you have any questions about using Alflorex for Colon Irritable with medications, seek advice from your doctor or pharmacist.

Can I take Alflorex for IBS with antibiotics?

As happens with most bacterial cultures, a dose of antibiotics could inactivate the bacterial culture in Alflorex. If you are prescribed a course of antibiotics, we advise that you take the dose of the antibiotic at a different time of day to when you take your daily Alflorex.

Can Alflorex for Irritable Colon be taken with antispasmodics, antidiarrheals, laxatives or products containing mint oil?

Yes. Alflorex for IBS can be taken with all or any of these products. To date, there are no known interactions of Alflorex with dietary supplements or medicines.

Can Alflorex be taken during pregnancy and breastfeeding?

There is no evidence available that Alflorex capsules should not be used during pregnancy and breast-feeding.

Alflorex for IBS contains strain 35624 of Bifidobacterium longum, a probiotic strain that is part of the bifidobacteria family that mothers transmit to their babies at birth and are also present in breast milk. These species are the first to colonize the newborn"s intestine.

Is Alflorex for IBS suitable for people with Crohns disease or Ulcerartive Colitis?

There are no clinical studies to support the efficacy of Alflorex for IBS in Crohn"s disease or Ulcerative Colitis.

If in doubt before taking Alflorex for IBS, consult a doctor or health care professional.

About PrecisionBiotics cultures

What are PrecisionBiotics cultures?

PrecisionBiotic cultures are unique bacterial cultures that have been specifically researched and rigorously tested by scientists at PrecisionBiotics Ltd.

All products contain bacteria that occur naturally in the human gut and are at home there.

PrecisionBiotics spend many years observing and testing them in real people to ensure they have the precise features needed and that they meet our rigorous safety standards.

To ensure that they reach the gut in optimal conditions, PrecisionBiotics™ has created special formulations and confirmed its activity in the gut, meeting the highest requirements for scientific testing and clinical trials in humans. These formulations are stable and therefore ensure that none of the products containing them need refrigeration.

PrecisionBiotics means specific bacteria, in the right amount.

How do bacterial cultures in food supplements compare with those in yoghurts?

Yogurts are made by fermenting milk with lactic acid-producing bacterial cultures, such as Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (starting cultures) that are added during the manufacturing process.

The starting strains used in these fermentation processes to make yogurts are not native to the human gut and have not been tested in clinical trials.

Many yoghurts contain live bacterial cultures, but these are usually chosen to make good yoghurt, not for their activity in the human gut. If bacterial cultures have been added during the manufacturing process, they may not be cultures that have been tested in clinical trials or that are native to the human gut.

In contrast, the 35624 culture of Alflorex for IBS is a highly specialized strain that has been isolated from the human gut, and which by scientific methods has been selected to obtain a targeted therapeutic action.

Is it worth taking several bacterial strains together?

We"re sometimes asked why PrecisionBiotics products contain only one or two types of bacteria, instead of a mix of five or even ten types.

As scientists, we know that mixing multiple bacterial cultures can mean their individual features are affected. Different cultures behave in different ways and may even have competing effects. Cultures of animal or plant origin may not be native to the human gut, so we do not add them.

It is the specific culture of bacteria and how that culture interacts with your unique gut bacteria that determines whether you will notice a difference.

So, PrecisionBiotics focus is on investing to find the best bacterial culture for each specific gut action. We then put each culture through a rigorous series of tests, culminating in clinical trials in the UK and Europe.

They produce a pure formulation, with no added bulk yoghurt or animal cultures, to provide a PrecisionBiotic product that they can guarantee and that clinicians can recommend.

They also guarantee that the number of bacteria is the optimal amount for each PrecisionBiotic product and how it works in the human gut.

Probiotics, prebiotics and symbiotics

What are probiotics?

The term probiotic is a word meaning "pro-life".

On this base, probiotics have been defined as "living microorganisms that confer a health benefit for the body when administered in adequate amounts".

What are the health benefits of probiotics?

Probiotics are increasingly used and evaluated on digestive balance function. Many clinical studies demonstrate the importance of probiotics in improving gut health and for stimulating immune function.

However, different probiotics can also have different benefits. Studies investigating the health effects of probiotics have been documented in areas such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBD), vaginal infections, immune enhancement, atopic eczema, rheumatoid arthritis and liver cirrhosis.

What are prebiotics?

Prebiotics are non-digestible dietary ingredients, whose function is to stimulate the growth or activity of some bacteria of the gut microbiota, resulting in a health benefit.

What are symbiotics?

Symbiotic is the combination of probiotics and prebiotics.


Do you have any questions or would you like to know more about our products? Do you have any comments or experiences to share with us?

Our customer service team is at your disposal to help you.

If you have a question, please call us at the following phone number (+34) 916 570 659,

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Phone: (+34) 916 570 659

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Address: Carretera de Irún

km 26,200.

28709 San Sebastián de los Reyes

(Madrid). España.

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